Objectives: The aim of this study was to compare the
cytokine levels of subjects with nasal polyps (NP) and
comorbid asthma and NP patients without asthma.
Patients and Methods: Thirty patients with NP (15
asthmatic and 15 nonasthmatic) were included in this
prospective study. Nasal secretion samples were collected
from the nasal cavities of all subjects. The levels
of eleven cytokines (TNF-a, TNF-b, IL-1b, IL-2, IL-4,
IL-5, IL-6, IL-8, IL-10, IL-12, and IFN-g) were measured
using flow cytometric method.
Results: The concentrations of Th2 cytokines IL-5, IL-6
and IL-10 were significantly higher in patients with NP
and asthma compared with subjects with NP without
asthma. IFN-g, IL-4, IL-6 and IL-10 levels were found
significantly higher in allergic patients with NP and
asthma compared with those without asthma. In nonallergic
patients with NP and asthma, the concentrations
of TNF-a, IL-5 and IL-6 were significantly higher than in
nonallergic patients with NP without asthma.
Conclusion: Our results showed that the presence of
Th2 cytokines, especially IL-5 and IL-6 in patients with
NP and asthma is a prominent feature that relates to
increased eosinophilic inflammation. We also found significant
influence of asthma and allergy on the cytokine
profiles in nasal secretions of patients with NP.
FREE FULL TEXTAnahtar Kelimeler: Alerji; astım, sitokinler; nazal polipler;nazal sekresyonlar.