E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat The results of combined treatment (surgery and postoperative radiotherapy) for tongue cancer and prognostic factors [Tr-ENT]
Tr-ENT. 2007; 17(1): 1-6

The results of combined treatment (surgery and postoperative radiotherapy) for tongue cancer and prognostic factors

Ahmet Karadeniz1, Mert Saynak, Züleyha Kadehci, Merdan Fayda, Görkem Aksu, Hümeyra Kocaelli, Günter Hafız

Objectives: We evaluated the results of surgical treatment
and postoperative radiotherapy and prognostic factors
in patients with primary tongue carcinoma.
Patients and Methods: The study included 60 patients
(31 males, 29 females; median age 54 years; range 22 to
82 years) who underwent surgery and postoperative radiotherapy
for oral tongue cancer. Tumor staging based on
the AJCC-1997 criteria was as follows: stage I (n=1), stage
II (n=21), stage III (n=12), and stage IVA (n=26). Surgery
included hemiglossectomy (n=46, 76%), partial (n=13,
22%) and total (n=1, 2%) glossectomy. Neck dissection
was performed in 47 patients (78%). Radiotherapy dose
was generally 6000 cGy/30 fr. The median follow-up was
51 months (range 5 to 180 months).
Results: The five-year overall and relapse-free survival
rates were 50% and 47%, respectively. Survival at five
years was 70% for stage I-III, and 20% for stage IVA. Most
of the relapses occurred in the first two years after treatment.
Recurrences were encountered in 31 patients
(52%). The median survival after recurrence was eight
months (range 1 to 53 months). In multivariate analyses,
significant prognostic factors for overall survival and
locoregional control were tumor size, stage, N stage,
extracapsular lymph node spread, and total duration of
radiotherapy. Complications were within acceptable limits.
Conclusion: Postoperative radiotherapy should be standard
for patients with stage III and IVA tongue cancer.

Keywords: Squamous cell carcinoma; prognosis; radiotherapy;tongue neoplasms.

Dil kanserinde kombine tedavi (cerrahi ve radyoterapi) sonuçları ve prognostik faktörler

Ahmet Karadeniz1, Mert Saynak, Züleyha Kadehci, Merdan Fayda, Görkem Aksu, Hümeyra Kocaelli, Günter Hafız

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Anahtar Kelimeler: Skuamöz hücreli karsinom; prognoz; radyoterapi;dil neoplazileri.

Ahmet Karadeniz, Mert Saynak, Züleyha Kadehci, Merdan Fayda, Görkem Aksu, Hümeyra Kocaelli, Günter Hafız. The results of combined treatment (surgery and postoperative radiotherapy) for tongue cancer and prognostic factors. Tr-ENT. 2007; 17(1): 1-6

Corresponding Author: Ahmet Karadeniz
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