E-ISSN 2602-4837
Tr-ENT. 2019; 29(2): 61-66 | DOI: 10.5606/Tr-ENT.2019.36036

Evaluation of volumetric and morphological changes of vestibular schwannomas following CyberKnife therapy

Engin Ugur Yardimci1, Melda Apaydin2, Fazıl Gelal2, Fatih Dag3, Ali Olmezoglu4, Ali Firat Sarp5
1Department of Radiology, Isparta City Hospital, Isparta, Turkey
2Department of Radiology, Katip Çelebi University, Atatürk Training and Research Hospital, Izmir, Turkey
3Department of Radiology, Turgutlu State Hospital, Manisa, Turkey
4Department of Radiation Oncology, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
5Department of Radiology, Lokman Hekim Hospital, Muğla, Turkey

INTRODUCTION: This study aims to evaluate volumetric and morphological changes following CyberKnife radiotherapy of vestibular schwannomas.
METHODS: Between March 2011 and December 2013, a total of 39 patients (15 males, 24 females; mean age 52 years; range, 19 to 86 years) who underwent CyberKnife hypofractionated radiotherapy were retrospectively analyzed. Tumor volume calculations were done by manual segmentation. Tumor morphology was classified by arbitrary cystic scaling. Local tumor control, tumor progression, transient swelling rates, and changes in tumor morphology were evaluated.
RESULTS: Local tumor control and transient swelling rates were 87% and 46%, respectively. Cystic tumors responded better than solid tumors to treatment as evidenced by volume reduction rates (87% vs. 58%), although local control rates were not significantly different (93% vs. 83%). Transient swelling rates were significantly higher in cystic tumors than in solid tumors (67% vs. 29%). Post-treatment volume changes were not correlated with gender, age group, or pre-procedural tumor volume.
DISCUSSION AND CONCLUSION: CyberKnife radiotherapy is an effective way of achieving local tumor control in patients with vestibular schwannomas. Although higher rates of volumetric regression would be expected in more cystic tumors than more solid tumors, local control rates are similar.

Keywords: CyberKnife, hypofractionated stereotactic radiotherapy, vestibular schwannoma

Engin Ugur Yardimci, Melda Apaydin, Fazıl Gelal, Fatih Dag, Ali Olmezoglu, Ali Firat Sarp. Evaluation of volumetric and morphological changes of vestibular schwannomas following CyberKnife therapy. Tr-ENT. 2019; 29(2): 61-66

Sorumlu Yazar: Melda Apaydin, Türkiye
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