E-ISSN 2602-4837
Travmatik fasyal paralizili sıçanların sinir iyileşmesinde E vitaminiyle beraber kortikosteroid ve tek başına E vitamini uygulanmasının etkileri [Tr-ENT]
Tr-ENT. 2010; 20(5): 255-259

Travmatik fasyal paralizili sıçanların sinir iyileşmesinde E vitaminiyle beraber kortikosteroid ve tek başına E vitamini uygulanmasının etkileri

Perihan Taşkale1, İlhan Topaloğlu

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Anahtar Kelimeler: Kortikosteroid; fasyal paralizi; E vitamini

The healing effects of vitamin E with corticosteroid and vitamin E alone on nerve healing in rats with traumatic facial palsy

Perihan Taşkale1, İlhan Topaloğlu

Objectives: We aimed to document the effects of vitamin
E and vitamin E plus corticosteroid on nerve healing in
rats.
Materials and Methods: Twenty-four Wistar Albino type
female rats were used in the study. The rats were divided
in to three groups, each with eight rats. Group 1 was
given methylprednisolone and Vitamin E, group 2 was
given Vitamin E alone and group 3 was the control group.
The buccal branch of the facial nerve was found under
anesthesia in all rats. After nerve identification, the stimulation
thresholds were assessed by Xomed Trace Nerve
Integrity Monitor NIM-2. The buccal branch of each facial
nerve in group 1 and 2 was traumatized by a vascular
clamp for an hour. After trauma the stimulus thresholds
were identified again. The nerve was not traumatized in
group 3. Group 1 was given 0.1 mg/kg/day vitamin E intramuscular
(i.m) and 1 mg/kg/day methylprednisolone i.m
for one month, group 2 was given 0.1 mg/kg/day vitamin
E i.m for one month and the control group was given 2
cc 0.09% NaCl subcutaneously every other day for one
month. At the end of a month the stimulus thresholds were
measured again and compared statistically.
Results: Mean stimulus threshold was 0.12 mA for all
of the groups at the beginning of the experiment. After
trauma mean stimulus threshold was 0.48 mA for the
group 1 and 2. At the end of one month stimulus threshold
was 0.22 mA for the group 1 and 0.33 mA for the group 2.
The stimulus threshold in the control group was measured
as 0.12 mA.
Conclusion: We concluded that the vitamin E has a positive
effect on nerve healing and corticosteroid enhances
its effect.

Keywords: Corticosteroid; facial paralysis; vitamin E.

Perihan Taşkale, İlhan Topaloğlu. The healing effects of vitamin E with corticosteroid and vitamin E alone on nerve healing in rats with traumatic facial palsy. Tr-ENT. 2010; 20(5): 255-259

Sorumlu Yazar: Perihan Taşkale
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