E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat [Tr-ENT]
Tr-ENT. 2018; 28(1): 26-33 | DOI: 10.5606/Tr-ENT.2018.02779

Expression of roundabout receptor family members 1 and 2 in laryngeal squamous cell carcinoma and correlation with clinical and pathological parameters

Ayşe Eren1, Ender Coşkunpınar1, Kadir Serkan Orhan2, Deniz Kanlıada2, Önder Şahin3, Mustafa Ömür Köse3, Turgay İşbir4, İlhan Yaylım1
1Department of Molecular Medicine, Institute of Experimental Medicine, İstanbul University, İstanbul, Turkey
2Department of Otolaryngology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
3Department of Neurology, Neuromuscular Pathology Unit, İstanbul University, İstanbul Faculty of Medicine, İstanbul, Turkey
4Department of Medical Biology, Faculty of Medicine, Yeditepe University, İstanbul, Turkey

INTRODUCTION: This study aims to investigate whether there is a role of ROBO-1, ROBO-2 and TGM-3 gene expression levels in the development of laryngeal cancer.
METHODS: The study was completed with 29 patients who underwent total or partial laryngectomy due to squamouscell laryngeal cancer. Gene expression analysis was performed by quantitative real-time polymerase chain reaction (qRT-PCR). Expression ratios were transformed into fold changes and reported as relative expression. Obtained fold changes were compared between different tumor grades in addition to normal tissue samples.
RESULTS: The ROBO-1, ROBO-2 and TGM-3 genes were expressed at a lower level than the control group.
DISCUSSION AND CONCLUSION: Our study results showed that there was no correlation between ROBO-1, ROBO-2 and TGM-3 gene expression and development of laryngeal cancer.

Keywords: Gene expression, laryngeal carcinoma, Roundabout 1, TGM-3.

Ayşe Eren, Ender Coşkunpınar, Kadir Serkan Orhan, Deniz Kanlıada, Önder Şahin, Mustafa Ömür Köse, Turgay İşbir, İlhan Yaylım. Expression of roundabout receptor family members 1 and 2 in laryngeal squamous cell carcinoma and correlation with clinical and pathological parameters. Tr-ENT. 2018; 28(1): 26-33

Sorumlu Yazar: Önder Şahin, Türkiye
LookUs & Online Makale